Widodo et al.[2] observed prevalence of hypokalemia in 23% (n = http://www.selleckchem.com/products/Lenalidomide.html 105) of the hospitalised patients with infectious disease and Kalita et al. studied 16 patients with dengue fever with quadriparesis, in seven, the pure motor quadriparesis was due to myositis.[6] Hypokalemia in association with infectious diseases, particularly in dengue fever, has been reported. Hypokalemic paralysis secondary to chikungunya fever has also been documented.[7] The putative mechanism of the hypokalemia in our patients could be either due to redistribution of potassium in cells or transient renal tubular abnormalities leading to increased urinary potassium wasting. Preliminary investigations were not suggestive of renal tubular abnormalities. However, transient self-limiting renal tubular defects secondary to infections cannot be ruled out.

Increased catecholamine levels in response to stress of the infection and secondary insulin release may result in an intracellular shift of potassium and hypokalemia. Anabolic states following rapid cell re-growth in patients of pernicious anemia treated with vitamin B12 and in patients with neutropenia after treatment with a granulocyte-macrophage colony stimulating factor can result in hypokalemia due to a potassium shift into cells.[8] ACKNOWLEDGMENT We owe thanks to the patient and her relatives for having patience and their contribution to this undertaking. Footnotes Source of Support: Nil. Conflict of Interest: None declared.

India is home to more than 5300 communities that include the Caste groups, Scheduled Tribes, Scheduled Castes, Particularly Vulnerable Tribal Groups (PTGs), religious groups, minority groups, and ethnic groups,[1] and these various groups have well adapted to the different ecological zones of the country. The Great Himalayas and the seas mark off the country from the rest of Asia giving it a distinct geography, varied socio-biological diversity, and different ecological climates. The fertility and mortality rates of any population group reflect its successful adaptation to the environment which the group inhabits. For example, a higher mortality rate may be indicative of poor environmental conditions besides other factors. These in turn are maintained by the process of natural selection. Natural selection is a continuous process that operates in populations to weed out deleterious genes and preserve the genes that increase the chances of survival, procreation, and multiplication.

The fitness of a population group is measured in terms of its Drug_discovery differential fertility and mortality. These are the most fundamental events through which natural selection is operative. Selection intensity is a measure of the fitness of a population, expressed in terms of differential fertility, and differential mortality, assuming that the heritability of fitness is complete,[2] and that both, the birth and the death rates, are selective.