To better understand the clinical significance
of such anatomical changes, we studied FA values in a whole-brain analysis comparing paranoid schizophrenic patients with a history of auditory hallucinations and matched healthy controls. The relationship of WM changes to psychopathology was assessed by correlating FA values with PANSS scores (positive symptoms and severity Of auditory hallucinations) and with Geneticin ic50 illness duration Schizophrenic patients showed FA reductions indicating WM integrity disturbance in the prefrontal regions, external capsule, pyramidal tract, occipitofrontal fasciculus, superior and inferior longitudinal fasciculi. and corpus callosum. The arcuate fasciculus was the only tract which showed increased FA values in patients. Increased FA values in this region correlated with increased seventy of auditory hallucinations and length selleck compound of illness. Our results suggest that local changes in anatomical integrity of WM tracts
in schizophrenia may be related to patients’ clinical presentation. (C) 2009 Elsevier Ireland Ltd. All rights reserved”
“Infants <1 year of age have a high prevalence of prognostically unfavorable leukemias and a presumed susceptibility to treatment-related toxicities. A total of 125 infants with acute myeloid leukemia (AML) were treated in studies AML-BFM-98 (n = 59) and -2004 (n = 66). Treatment regimens of both studies were comparable, consisting of intensive induction followed by four courses (mainly high-dose cytarabine and anthracyclines). Allogeneic-hematopoietic stem-cell-transplantation (allo-HSCT) in 1st remission was optional for high-risk (HR) patients. Most infants (120/125 = 96%) were HR patients according to morphological, cytogenetic/molecular
genetic and response criteria. Five-year overall survival was 66 +/- 4%, and improved from 61 +/- 6% in study-98 to 75 +/- 6% in study-2004 (P-logrank 0.14) and event-free survival rates were 44 +/- 6% and 51 +/- 6% (P-logrank 0.66), respectively. Results during in HR infants were similar to those of older HR children (1-<2- or 2-<10-year olds, P-logrank 0.90 for survival). Survival rates of HSCT in 1st remission, initial partial response and after relapse were high (13/14, 2/8 and 20/30 patients, respectively). The latter contributes to excellent 5-year survival after relapse (50 +/- 8%). Despite more severe infections and pulmonary toxicities in infants, treatment-related death rate was identical to that of older children (3%). Our data indicate that intensive frontline and relapse AML treatment is feasible in infants, toxicities are manageable, and outcome is favorable. Leukemia (2012) 26, 654-661; doi:10.1038/leu.2011.267; published online 4 October 2011″
“In this paper.