3, P = 0.01), CMV infections (HR 1.6, P = 0.001), and AMR (HR 1.5, P = 0.002). The significantly worse graft survival in the alemtuzumab cohort may be due to the increased rates of AMR and infectious complications.”
“Compressive intradural metastases of the cauda equina are a rare site of metastatic spread in systemic cancer. So far, only few reports have been published with conflicting statements concerning a surgical versus nonsurgical approach.
Five patients with symptomatic space-occupying intradural metastases of the cauda equina were analyzed retrospectively, focusing on the influence
of surgical intervention on pain relief, neurological outcome and thus the patients’ quality of life.
At BTSA1 order the time of diagnosis, all patients were in an advanced metastatic state. Surgical resection was the primary treatment in four patients and radiotherapy in one. Despite infiltration of the cauda rootlets, gross total tumour resection could be achieved in two of the four patients treated surgically. Functional outcome was beneficial in these patients with marked and Fer-1 immediate relief of pain and improvement of motor function even following incomplete tumour resection.
Surgical treatment of compressive intradural metastases of the cauda equina seems to be feasible with low operative risk and with the potential benefit of an immediate relief of pain and improvement in
motor function and thus an increase in quality of life.”
“Study Design. Data collected prospectively from the Prospective Pediatric Scoliosis Study (PPSS) were analyzed statistically to address the hypothesis that covered specific aspects of treatment and its outcome.
Objective. To assess and contrast Scoliosis Research Society (SRS) outcome scores for patients assigned to one of three types of spinal instrumentation constructs. The study hypothesis was that the instrumentation strategy that provides the best curve correction will be associated with the best SRS scores.
Summary of Background Data. Surgical treatment of scoliosis has evolved
over time using implants and surgical techniques; however, quality of life indicators have not this website typically been analyzed to assess whether surgery and instrumentation will improve quality of life in pediatric patients.
Methods. Patients were assigned to one of three instrumentation groups depending on the type of construct used. The Scoliosis Research Society’s SRS-30 survey was used to measure patient outcomes comparing preoperative results to a 2-year follow-up.
Results. Changes in the SRS Pain, Activity, Appearance, Mental, Satisfaction, and SRS Total domains did not differ significantly among instrumentation groups for any time intervals. However, analysis of SRS Pain did show a significant change over time for all instrumentation patterns. The analysis of SRS Activity showed a significant change over time for all instrumentation patterns preoperatively to 2 years postoperatively.