However, other side effects, such as akathisia, are repeatedly reported. Further, none of the studies report longer-term outcomes. In the absence of alternatives, polypharmacy is

a common strategy in clinical practice. Combining aripiprazole with clozapine in clozapine-resistant or clozapine-intolerant patients seems to be worthy of further investigation from the pharmacological and clinical points of view.”
“Besides the well-known systemic immune deficiency, also a regional immune deficiency, labeled as immunocompromised district (ICD), has been documented and focused in the recent years. The objective of the study is to gain more insights into the mechanisms PF-00299804 molecular weight involved in systemic and local immune destabilization. A 35-year-old, homosexual, and drug-addicted HIV+ man presented with a single nodule of Kaposi sarcoma (KS) located on the penis, where a slow to heal herpes zoster had appeared 2 months before. It has been assumed that the unusual

penile location of herpes zoster facilitated the outbreak of KS in the affected dermatome because of a viral damage to sensory nerve fibers of the same dermatome. This damage, by interfering with the immunoregulatory function of neuropeptides released by nerve endings in that area, may have caused a regional alteration of the immune control favoring the local onset of the opportunistic angiogenic tumor (KS). In a few words, an ICD took place in an immunocompromised patient, thus introducing a more vulnerable site in an already vulnerable subject. The present case is the second one in the literature to document an ICD in the

setting of preexisting systemic immune deficiency.”
“Medication GSK461364 order overuse headache (MOH) can be considered a clinical condition at the boundaries between drug addiction and P005091 molecular weight chronic pain disorder. The common 196G > A single-nucleotide polymorphism of BDNF gene, resulting in a valine 66 to methionine (Val66Met), is related with behaviour disorders and substance abuse. With the aim of identifying a worsening factor in MOH, rather than the detection of a specific risk factor for the development of the disease, we investigated whether the presence of a functional BDNF polymorphism might determine clinical differences within a group of 90 MOH patients, particularly in monthly drug consumption, that is the hallmark of disease. Directly comparing MOH patients homozygous for G allele (G/G) with carriers of A allele (non-G/G), we have observed 47 G/G genotypes and 60 non-G/G genotypes. Non-G/G had a higher consumption of monthly drug number (Cohen’s d = 0.76) than G/G patients. At multiple regression analysis, the Val66Met BDNF polymorphism emerged as a significant independent predictor of analgesic drug consumption (Beta = 0.33, Cohen’s f (2) = 0.134). These findings showed an influence of examined BDNF polymorphism in the MOH clinical features, supporting the idea that MOH is a substance abuse disorder.

In addition, idebenone induced an increase in the total RNA of the pro-apoptosis protein BAX, it also increased the caspase-3 activity in the cell lysates when compared with the untreated control cells or cells exposed to 10 mu M or lower BAY 73-4506 solubility dmso concentrations of idebenone. The detrimental effect of idebenone was attenuated by glutathione, an antioxidant, suggesting that oxidative stress contributed to the idebenone-induced cell death. In conclusion, our results suggest that antioxidant idebenone induced apoptosis when used in high concentrations.”
“This article explores the behavior

of interface thermal conductance of longitudinally connected ( 6,6) nanotubes-connected through CH(2) linkages-using nonequilibrium molecular dynamics (NEMD) and wave packet simulations. Here, we study the effect of connected linkers on the interface thermal conductance and thermal energy transmission coefficients for several phonon modes. Our simulation results suggest that interface thermal conductance between nanotubes strongly depends on the number of CH(2) linkers. The more the number Selleck Pexidartinib of CH(2) linkers, the higher the conductance.

Further insights into phonon energy transmission are provided from wave packet simulations. Here, we find that the behavior of transmission for various studied acoustic and optical phonon modes is complex in nature, where the thermal transmission coefficients do not always correlate with number of CH2 linkages. However, when the contributions from all the modes are added together, the overall interface thermal conductance agrees well with NEMD simulations. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3560914]“
“Evidence regarding the role of mercury

and aluminum in the pathogenesis of Alzheimer’s disease (AD) remains controversial. The aims of our project were to investigate the content of the selected metals in brain tissue samples and the use of a specific mathematical transform to eliminate the disadvantage of a strong positive skew in the original data distribution. AZD1480 in vivo In this study, we used atomic absorption spectrophotometry to determine mercury and aluminum concentrations in the hippocampus and associative visual cortex of 29 neuropathologically confirmed AD and 27 age-matched controls. The Box-Cox data transformation was used for statistical evaluation. AD brains had higher mean aluminum concentrations in the hippocampus than controls (0.357 vs. 0.090 mu g/g; P = 0.039) after data transformation. Results for mercury were not significant. Original data regarding microelement concentrations are heavily skewed and do not pass the normality test in general. A Box-Cox transformation can eliminate this disadvantage and allow parametric testing.

There is a lack of evidence-based treatment guidelines for both acute and long-term management of ocular myasthenia. Acute management of myasthenic crisis requires intensive

monitoring of the Navitoclax concentration patient and institution of an efficient and safe treatment such as plasma exchange. Patient education is essential to a comprehensive long-term treatment plan.”
“Background: Plasma metal ion levels are commonly used in the postoperative follow-up evaluation of patients who have had a metal-on-metal hi p,arthroplasty. However, the relationship between these levels and clinical and imaging findings is not well known.

Methods: We evaluated 156 consecutive patients who received a unilateral ASR XL total hip replacement. Patients presented, regardless of symptoms, in response to HM781-36B a voluntary recall of the hip replacement by the manufacturer and were assessed with regard to the presence and type of symptoms and plasma cobalt-chromium levels. In addition, radiographic and magnetic resonance imaging studies were performed and analyzed.

Results: Eighty patients were asymptomatic, and seventy-six

patients were symptomatic. The median cobalt level was 1.8 ppb, and the median chromium level was 1.0 ppb (at or below measurement threshold). Pseudotumors that could be detected on magnetic resonance imaging were seen in 69% (107) of 156 patients, and radiographic osteolysis was evident in 7% (eleven patients). At a threshold of 5 ppb, no association was detected between abnormal metal ion levels and patient symptoms, prosthetic femoral head size, or acetabular cup inclination. An abnormal cobalt level was significantly associated with the presence of periprosthetic lucency on radiographs and pseudotumor on magnetic resonance imaging (p < 0.05). An abnormal chromium level showed a similar pattern, but the relationships did not reach significance. Both abnormal plasma

cobalt and chromium levels were associated with larger sizes of pseudotumor when present (p < 0.05).

Conclusions: In our sample, with a threshold of 5 ppb, abnormal plasma metal ions were associated with larger Cilengitide order sizes of pseudotumors when present, but were not predictive of patient symptoms. Abnormal plasma cobalt levels have a significant association with periprosthetic lucency and presence of pseudotumor. Plasma chromium shows a similar pattern of association with lucency and presence of pseudotumor, although the relationships were not significant. Metal ion analysis should be used in conjunction with clinical and imaging evaluation and not as a sole indirect screening test when evaluating patients following metal-on-metal hip arthroplasty.”
“Hydrophobically modified polymers were synthesized via esterification reactions between a commercial triblock copolymer composed of ethylene oxide (EO) and propylene oxide (PO) segments (EO(20)PO(70)EO(20)) and lauric and oleic acids.

This innovative process GSK923295 in vitro showed maximization of alpha-amylase and proteases production when mixtures were used compared to the isolated substrates and can be extended to other enzymes groups for obtaining multi-enzyme complex. (C) 2013 Elsevier B.V. All rights reserved.”
“Non-invasive measurement of intracranial pressure (ICP) reduces the complications and cost for both patient and health care systems. Improvement of non-invasive methods has led to development of systems for reproducing continuous, real-time non-invasive ICP signals. So far, non-invasive methods have been tailored for the patients with head trauma. We have used Schmidt’s auto-adaptive method to assess the accuracy of

this method for patients after surgery for supratentorial

brain tumors. Data from forty patients with the diagnosis of brain tumor operated from 2008 to 2010 were used to estimate the accuracy of Schmidt’s method in our patients. We obtained the model parameters from 30 recordings. We determined the ICP wave form for the remaining patients by both invasive and non-invasive techniques. In JQ1 supplier the test group, by invasive method, the mean ICP +/- 2SD was 17.1 +/- 6.6 mmHg and using non-invasive method, the mean ICP +/- 2SD was 16.5 +/- 5.4 mmHg. The calculated error was 4.6 mmHg using root mean square errors. The average Pearson correlation between the estimated and real waveforms was 0.92. We believe that application of this method is acceptable

for post-operative assessment of ICP in brain tumor patients.”
“Purpose: To evaluate the effects of the methanol extract of Acanthus montanus on guinea pig trachealis muscle.

Methods: Guinea pig tracheae were set up in 10 ml organ baths. The effect of the methanol extract of Acanthus montanus (0.5 – 8 mg/ml) on the spontaneous tone of the trachea and selleck chemical carbacholprecontracted trachea in the absence and presence of propranolol, glibenclamide and procaine was studied.

Results: The extract (0.5 – 8.0 mg/ml) produced a concentration-dependent relaxation of the intrinsic tone in tracheal preparations which was completely blocked by propranolol (3 x 10(-7) M), glibenclamide (10(-7) M) and procaine (10(-3) M). The extract (0.5 – 8 mg/ml) produced a concentration-dependent relaxation of carbachol (10(-5) M)-precontracted trachea. This effect of the extract was partially blocked by propranolol (3 x 10(-7) M), procaine (10(-3) M) and glibenclamide (10(-7) M) with a progressive increase in the median effective concentration (EC50) values as follows: control, 0.66mg/ml > propranolol, 1.42mg/ml > glibenclamide, 1.54mg/ml > procaine, 2.04 mg/ml.

Conclusion: The results obtained suggest that the extract produces a non-specific smooth muscle relaxant effect mediated via beta-adrenergic receptor mechanism or potassium channels.

58); overall SC averaged 36.7 +/- 2.3 cm. Percentage of live sperm was not different (P = 0.24) between NE bulls (80%) than EI bulls (67%) in July and August. Bulls grazing NE fescue had more (P < 0.06) motile sperm than

EI bulls in July and August. Percentages of progressive (57 vs. 38%, NE and EI, respectively; P < 0.06) and rapid (67 vs. 46%, NE and EI, respectively; P = 0.04) sperm were greater from bulls grazing NE than EI bulls in July and August. Average velocity of the smoothed sperm path and progressive velocity in a straight line from the beginning to GSK1904529A price the end of the sperm track were slower (P < 0.09) in EI bulls than NE bulls and were slower (P = 0.04) in August compared with July. Mean width of head oscillation as the sperm swims was less (P < 0.06) in August than July. Concentrations of cortisol and testosterone were not (P > 0.10) influenced by fescue type. Semen from bulls grazing EI had reduced motility and morphology than bulls grazing NE. Detrimental effects BMS-777607 chemical structure of toxic fescue may not be mediated by cortisol, testosterone, or both. Semen quality of bulls grazing toxic EI tall fescue was decreased with increased maximum ambient temperatures.”
“The objective of this work was to investigate plasma modification of viscose for environmentally friendly flame-retardant cellulosic materials.

Sodium silicate layers were predeposited onto viscose and cotton flannel substrates and grafted/crosslinked using atmospheric pressure

plasma. The modified cellulosic fabrics tested A-1210477 price with the automated 45 degrees angle test chamber showed significant improvement in their flame-retardant properties. Analysis conducted by TGA and DSC exhibited enhanced thermal stability of the treated fabrics. Furthermore, the surface analysis (XPS and SEM) confirmed the presence of the SiO2 network attached to the substrate even after intense ultrasound washes. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“Rheumatoid arthritis (RA) is associated with progressive joint destruction, with functional status influenced by both disease activity and radiographic progression. The case for early aggressive treatment of RA is based on large amounts of good data in many countries. Studies with conventional disease-modifying anti-rheumatic drugs in early RA have shown improved outcomes compared with later treatment, especially if an aggressive approach with combinations of drugs is used. Early intervention with tumour necrosis factor (TNF) inhibitors has been shown to improve clinical outcomes, induce remission and prevent radiographic progression. It also improves patients’ functional status, health-related quality of life, and reduces fatigue. Patients with RA have reduced productivity, an increased number of lost work days and retire early; enabling patients to work should be at the core of a therapy’s cost-effectiveness.

DSC

results indicate that there are nucleation effects of LiClO(4) on the crystallization of PEO. But, on the other hand, the coordination of lithium ion with the oxygen ether atoms of PEO can obviously reduce the Selleck ALK inhibitor crystallinity and spherulite growth rate of PEO. This contrary effect of LiClO(4) on the crystallization of PEO in PEO/LiClO(4) complexes system was analyzed and discussed in detail. The Laurizen-Hoffman theory was used to describe the Li-coordinated crystallization kinetics of PEO spherulite. It showed that the nucleation constant (Kg) and folding surface free energy (re) decreased with increasing LiClO(4) contents, and the energy necessary for the transport of segments across the liquid-solid interface (DE) increased on increasing the contents of LiClO(4). (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 123: 1935-1943, 2012″
“Objective: This study was designed to evaluate the antigen capture enzyme immunoassays (EIAs) Triage parasite panel and TechLab Entamoeba histolytica II in detecting Giardia intestinalis, Cryptosporidium sp, and Entamoeba BVD-523 research buy histolytica in fecal samples in comparison to microscopy, and in differentiating Entamoeba histolytica from Entamoeba dispar.

Methods: The Triage EIA was evaluated using 100 stool specimens that were tested by standard ova and parasite examination, including staining with both trichrome and modified

acid-fast stains. Differentiation between E. histolytica and E. dispar was performed using TechLab.

Results: Microscopic examination revealed that 19% of the samples were positive for Giardia, 4% for Cryptosporidium, and 1% for E. histolytica/E. dispar, and other parasites were found in 5%. By Triage, 23% of the samples were infected with Giardia, 5% with Cryptosporidium, and 2% with E. histolytica/E. dispar. Triage showed a sensitivity of 100% and specificity of 91.5%. The TechLab assay was negative for both samples diagnosed as E. histolytica/E. dispar by Triage, which suggested that they were BMS-345541 purchase E. dispar. Both tests showed no cross-reactivity with other intestinal protozoa.

Conclusion: These results indicate that antigen detection by EIA

has the potential to become a valuable tool, capable of making stool diagnostics more effective. (C) 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“Despite the advent of magnetic resonance imaging and musculoskeletal ultrasound, the plain radiographs of the hands and feet remain an important tool for a practising rheumatologist both in clinical and research settings. This review focuses on providing a historical overview of commonly used methods of scoring radiographs in rheumatoid arthritis and discusses technical issues related to radiographic scoring, limitations and advantages of radiographs, and current recommendations regarding reporting radiographic data in clinical trials.”
“Background.

Tumor volume and maximum diameter were measured on CT scans. Reciprocal of doubling time (DT) (RDT) was calculated. Analysis of variance and Student t tests were performed.

Results: Thirty-two clear cell learn more carcinomas, 10 papillary carcinomas, six chromophobe carcinomas, four oncocytomas, and one angiomyolipoma were analyzed. Median tumor size was 2.9 cm (range, 1-12 cm). Seven tumors did not increase in volume. DT ranged from -248 to 72 days (mean, 474 days; median, 811 days). Growth rate determined by using maximum diameter ranged from -10.8 to 33.2 mm/y (mean, 5.1 mm/y; median, 3.5 mm/y). Faster-growing tumors were more likely to be clear

cell carcinomas, those of higher grade had higher growth rates. No significant correlation was found between RDT and tumor initial volume, subtype, or grade. Small renal tumors (<= 3.5 cm) Selleckchem Selisistat were similar to larger tumors in subtype and growth rate. Age at diagnosis correlated negatively with renal tumor growth rate (P=.03).

Conclusion: Growth rates in renal tumors of different sizes, subtypes, and grades represent a wide range and overlap substantially. Small renal tumors appear to be similar to larger ones in nature. (C) RSNA, 2009″
“Background: German university medical centers are important institutions for scientific research,

academic teaching and patient care representing crucial components of academic education, medical specialist training and health services research. The aim was to analyze the structure and performance of the dermatology departments at German selleck inhibitor university medical centers.

Patients and methods: Nationwide survey of the heads of the dermatology departments at German university medical centers (n = 35) using a standardized questionnaire on the department’s performance profiles in inpatient and outpatient care, financial remuneration, research output and the anticipated development of the department.

Results:

Data from 2010 on 33 of 35 (94.3 %) dermatology departments at German university medical centers were analyzed. The mean number of inpatient beds of the departments was 57 (range 24-133) with a utilization of bed capacity of 86 % on average. The mean case mix of the 2,494 inpatient cases per year was 1,748, the reported mean case mix index was 0.83. On average, 21,973 cases (range 5,284-92,547) were treated at university outpatient clinics. Of the 33 participating departments of dermatology 22 were placed within the top third of their faculty regarding research funding. The most important components of patient care included surgical dermatology (31.4 %), dermato-oncology (16.9 %) and general dermatology (32.1 %).

Conclusions: Covering the whole spectrum of dermatology, the dermatology departments of German university medical centers show extraordinary performances in both patient care and scientific research.

5 to 10.8 years, with documented P. falciparum malaria in Kampala, Uganda. The patients belonged to one of three pre-study defined groups: uncomplicated malaria (UM), severe non-fatal malaria (SM-s), and fatal malaria (SM-f). Subset analysis was done on those with cerebral malaria (CM) or severe malaria anaemia LY3039478 purchase (SMA). Monocyte ICAM-1 was measured by flow cytometry. sICAM-1 was measured by enzyme immunoassay.

Results: Both sICAM-1 and monocyte cell-surface ICAM-1 followed a log-normal distribution. Median sICAM-1 concentrations increased with greater severity-of-illness: 279 ng/mL (UM), 462 ng/mL (SM-s), and 586 ng/mL (SM-f), p < 0.0001. sICAM-1 levels were not statistically different among children with CM compared

to SMA. Monocyte ICAM-1 expression was significantly higher in cases

of UM compared with SM-s or SM-f (p < 0.001) and was higher among the subset of patients with CM compared with SMA, p < 0.0014. The combination of sICAM-1 and cellular ICAM-1 identified distinct categories of patients (UM with low sICAM-1 and higher monocyte ICAM-1, CM with both sICAM-1 and monocyte ICAM-1 high, and SMA with sICAM-1 high but monocyte ICAM-1 low).

Conclusion: In this cohort of children with P. falciparum malaria, sICAM-1 levels were associated with severity-of-illness. Patients with UM had higher monocyte ICAM-1 expression consistent with a role for monocyte ICAM-1 in immune clearance during non-severe malaria. buy BTSA1 selleck kinase inhibitor Among the subsets of patients with either SMA or CM, monocyte ICAM-1 levels were higher in CM, consistent with the role of ICAM-1 as a marker of cytoadhesion.

Categories of disease in pediatric malaria may exhibit specific combinations of soluble and cellular ICAM-1 expression.”
“Twenty-year-old para 1 presented with acute puerperal uterine inversion. Manual reposition and O’sullivan methods were tried but failed. She refused for any other corrective procedure. She again presented after 10 months with chronic puerperal inversion. Haultain operation was done. At laparotomy, inverted uterus was unicornuate, right kidney and ureter were absent.”
“Poly(ether-block-amide) (PEBA) were prepared by means of a condensation reaction with polyamide-6 as hard segment and polyether as soft segment. The optimal reaction conditions were determined as the followings: 3% of water and 0.35% of catalyst, reaction temperature 260 degrees C +/- 5 degrees C and the reaction time 4 h under the N(2) atmosphere, and 1 h under the vacuum, the vacuum <80 Pa. Characterization results of FTIR and (1)H-NMR showed that the block copolymer of polyether and polyamide was synthesized successfully. The obtained PEBA was applied as an antistatic agent for the ABS resin. The research results showed that the blend with the best properties was PEBA2-2/ABS and the dosage of PEBA was 12%. PEBA2-2 could obviously decrease the surface resistivity of ABS from 10(14) to 10(10)Omega and also exhibit good persistent antistatic ability.

An excess of gray matter is not a usual finding in TLE. However, within a neurodevelopmental framework, retained gray matter is discussed as reflecting neurodevelopmental disruption. The findings indicate the importance of quantitative MRI for the detection of subtle secondary abnormalities in focal TLE and once more underline the importance of early seizure management in children with intractable TLE. (C) 2011 Elsevier Inc. All rights reserved.”
“In view of the remarkable decrease

of the relative heart weight and the relative blood volume in growing pigs, we investigated whether cardiac output (CO) and stroke volume (SV) of modern growing pigs are proportional to body mass (M), as predicted by allometric scaling laws: CO (or SV) = a.Mb, in which b is a multitude of 0.25 (quarter power scaling law). Specifically, we tested the hypothesis that CO scales with M to the power of 0.75 (CO = a.M(0.75)) Citarinostat in vivo and SV scales with M to the power of 1.00 (SV = a.M(1.0)) and investigated whether these relations persisted during increased cardiac stress. For this purpose, 2 groups of pigs (group 1 of 57 +/- 3 kg in Lelystad, and group 2 of 28 +/- 1 kg in Rotterdam) were chronically instrumented

with a flow probe to measure CO and SV; instrumented pigs were studied at rest and during strenuous exercise (at similar to 85% of maximum heart rate). Analysis of both groups of pigs (analyzed separately or combined) under resting conditions demonstrated that the 95% confidence Crenigacestat mw intervals Adavosertib concentration of power-coefficient b for CO encompassed 0.75 and for SV encompassed 1.0. During exercise, similar results were obtained, except for SV in group 2, in which the 95% confidence limits remained below 1.0, which may have been due to the relatively small range of BW in group 2. These observations indicate that CO and SV of growing pigs with M less than 75 kg are still proportional to

M, even during strenuous exercise, and that CO and SV scale with M according to the quarter power scaling laws. In conclusion, the concerns about disproportional growth and development of modern growing pigs with BW up to 75 kg were not confirmed by the present study.”
“N-Benzyl-O-carboxymethyl chitosan (OCChB) was synthesized through a reaction of O-carboxymethylchitosan (OCCh) and benzaldehyde by the reductive amination method. The chemical structures and physical properties of the derivatives were confirmed by Fourier transform infrared spectroscopy and 1H-NMR. The cytotoxicity of the polymers was tested by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay at concentrations ranging from 0.01 to 1000 mu g/mL. The substitution degrees of the derivatives, calculated by 1H-NMR, were 12 and 53% for OCChB1 and OCChB2, respectively.

The addition of chlorhexidine also contributed to inhibition of the action of phenol.

This approach provides a suitable and effective means of diluting and removing any excess or residual phenol from the exposed area.”
“Geranylgeranoic acid (GGA) is one of the most potent cancer-preventive acyclic retinoids. GGA has been shown to induce cell death in human hepatoma-derived HuH-7 cells. We have recently reported the natural occurrence of GGA and its related compounds in several medicinal herbs such as turmeric, basil, rosehip, cinnamon and others [Shidoji and Ogawa, J. Lipid Res., 45: 1092-1103, 2004]. En the present study, we performed oral administration of turmeric tablets to healthy volunteers in order to investigate bioavailability of natural GGA. By using liquid chromatography/mass spectrometry, authentic GGA was eluted at a retention time of around 18 min as a negative ion of m/z 303.4. With healthy CRM1 inhibitor volunteers,

plasma GGA was detected prior to the tablet intake and its concentrations were increased at 2 h after its intake and maintained at higher level until 4 h, suggesting an efficient bioavailability of preformed GGA in the turmeric tablets through oral administration. find more These results indicated that GGA in the turmeric tablet was absorbed as an intact form from intestinal mucosa. The present study provides a clue to conduct a research for cancer preventive roles of GGA in a number of spices.”
“A low-formaldehyde-emission methylol AS1842856 mw urea/triethanolamine composite was synthesized

through in situ esterification of formaldehyde with triethanolamine and subsequent copolymerization of the synthesized polyester with methylol urea. The effects of the addition of triethanolamine to the polymerization process on some physical properties of the synthesized copolymer were evaluated. The copolymer was characterized with IR spectroscopy and macrophase-separation techniques. At a given triethanolamine concentration, the composite exhibited macrophase-separation behavior between that of pure methylol urea and pure polyester. IR spectra showed the presence of the polyester moiety in the composite. The values of the moisture uptake, formaldehyde emission, melting point, and elongation at break of the copolymer were within acceptable levels required in the coating industry. Therefore, the methylol urea/polyester copolymer resin could have potential as a binder in the coating industry. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 116: 645-653, 2010″
“Daptomycin is a Food and Drug Administration-approved alternative to vancomycin for the treatment of serious methicillin-resistant Staphylococcus aureus infections in adults. Treatment failure with daptomycin is increasingly reported in adults, but data in children are limited.