“OBJECTIVE: The ideal ratio between liver graft mass and

“OBJECTIVE: The ideal ratio between liver graft mass and recipient body weight for liver transplantation in small infants is unknown; however,

if this ratio is over 4%, a condition called large-for-size may occur. Experimental models of large-for-size liver transplants have not been described in the literature. In addition, orthotopic liver transplantation is marked by high morbidity and mortality rates in animals due to the clamping of the venous splanchnic RSL3 chemical structure system. Therefore, the objective of this study was to create a porcine model of large-for-size liver transplantation with clamping of the supraceliac aorta during the anhepatic phase as an alternative to venovenous bypass.

METHOD: Fourteen pigs underwent liver transplantation with whole-liver grafts without venovenous bypass and were divided into two experimental groups: the ARRY-162 control group, in which the weights of the donors were similar to the weights of the recipients; and the large-for-size group, in which the weights of the donors were nearly 2 times the weights of the recipients. Hemodynamic data, the results of serum biochemical analyses and histological

examination of the transplanted livers were collected.

RESULTS: The mortality rate in both groups was 16.5% (1/7). The animals in the large-for-size group had increased serum levels of potassium, sodium, aspartate aminotransferase and alanine aminotransferase after graft reperfusion. The histological

analyses revealed that there were no significant differences between the groups.

CONCLUSION: This transplant method is a feasible experimental model of large-for-size liver transplantation.”
“Our objective is to report an interesting case of a patient with known severe vertebrobasilar disease who presented with isolated bilateral middle cerebellar peduncle (MCP) infarction. Isolated infarction of the MCP is uncommon, occurring in roughly 0.12% of acute strokes. Isolated bilateral MCP infarction is extremely rare and has been described in only a few cases in the literature. The MCP is a watershed zone between the anterior inferior selleck products cerebellar artery and the superior cerebellar artery and its occurrence suggests hypoperfusion.”
“Cannabis has long been known to produce cognitive and emotional effects. Research has shown that cannabinoid drugs produce these effects by driving the brain’s endogenous cannabinoid system and that this system plays a modulatory role in many cognitive and emotional processes. This review focuses on the effects of endocannabinoid system modulation in animal models of cognition (learning and memory) and emotion (anxiety and depression). We review studies in which natural or synthetic cannabinoid agonists were administered to directly stimulate cannabinoid receptors or, conversely, where cannabinoid antagonists were administered to inhibit the activity of cannabinoid receptors.

The results showed that dichloromethane extracted selectively and

The results showed that dichloromethane extracted selectively and effectively berberine and palmatine from Huangbai powder among the examined solvents. In addition, dichloromethane can be recycled and reused, making it a potential candidate for large scale extraction of berberine and palmatine from Huangbai.”
“Healthcare costs for low back pain (LBP) are

increasing rapidly. Hence, it is important to provide treatments that are effective and cost-effective. The purpose of this systematic review was to investigate the cost-effectiveness of guideline-endorsed treatments for LBP. We searched nine clinical and economic electronic databases and the reference list of relevant systematic reviews and included studies for eligible studies. Economic evaluations conducted alongside randomised 10058-F4 cell line controlled trials investigating treatments for LBP endorsed by the guideline of the American College of Physicians and the American Pain Society were included. Two independent reviewers screened search results and extracted data. Data extracted included the type and perspective of the economic evaluation, the treatment comparators, and the relative cost-effectiveness of the treatment comparators. Twenty-six studies were included. Most studies found that interdisciplinary rehabilitation, exercise, acupuncture, spinal manipulation or cognitive-behavioural therapy were cost-effective in people with sub-acute or chronic

LBP. Massage alone was unlikely to be cost-effective. There were inconsistent results on the cost-effectiveness of advice, AZD2014 molecular weight insufficient evidence on spinal manipulation for people with acute LBP, and no evidence on the cost-effectiveness of medications, yoga or relaxation. This review found evidence supporting the cost-effectiveness of the guideline-endorsed treatments of interdisciplinary rehabilitation, exercise, acupuncture, spinal manipulation and cognitive-behavioural therapy for sub-acute or chronic Epacadostat LBP. There is little or inconsistent evidence

for other treatments endorsed in the guideline.”
“Introduction: The pathogenesis of seborrheic dermatitis has not been fully elucidated. A number of anascogenic yeasts of Malassezia spp. appear to be involved in the intensity of the symptoms. The purpose of the study is to evaluate the levels of selected inflammatory cytokines, IL-2, IL-4, IFN-gamma and TNF-alpha, in the serum after treatment with itraconazole.

Material/Methods: Sixty-six subjects were enrolled in the study. The control group consisted of 30 participants (23 females and 7 males) without any clinical disorders, aged 24-65 (37.41 +/- 6.08 years). Thirty-six patients with seborrheic dermatitis (16 females and 20 males), aged 19-76 (38.61 +/- 13.77), constituted the study group. The measurement of IL-2, IL-4, IFN-gamma and TNF-alpha levels was performed by ELISA using a Human High Sensitivity kit (Diaclone, France).

A total of 163 consecutive morbidly obese individuals undergoing

A total of 163 consecutive morbidly obese individuals undergoing Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) in a single bariatric center in Finland were recruited. Fasting blood samples were drawn after 12 h of fasting before and 1 year after bariatric operation. Data for weight regain and medication were collected with a questionnaire after 3.1 +/- 2.7 years (mean +/- SD) follow-up. Nonalcoholic steatohepatitis (NASH) was diagnosed with liver histology. Twenty BMI- and 13 WHR-related SNPs were genotyped. Linear regression was used to identify

factors predicting weight loss and weight regain.

Lower baseline BMI predicted greater decline in BMI (p = 0.0005) and excess weight loss (EWL) buy NSC23766 (p = 0.009). In the multiple linear regression analysis age and BMI, explained the variance of EWL during the first year while GRS, sex, fasting plasma glucose, serum insulin and NASH diagnosis did not have any effect. None of the baseline clinical variables explained BMI regain. The combined GRS did not associate with weight or BMI at baseline, with 1-year changes or with weight regain between 1 year and an average of 3.1 years follow-up.

In our study, we AZD8931 found that the genotype risk score does not predict weight loss after obesity surgery while lower baseline BMI predicted the greater weight loss.”

In the absence of a national pediatric renal biopsy registry, there is a paucity of information on the pattern of childhood renal disease observed in Pakistan. A few studies previously reported are based on

light microscopic study of renal biopsies only. This is the first study from this country which is based on light, immunofluorescence and electron microscopic study of native renal biopsies.

Methods: We undertook Ricolinostat chemical structure a retrospective review of native renal biopsies performed in children who presented with signs and symptoms related to renal diseases at the Sindh Institute of Urology and Transplantation during the period of July 1995 to June 2008. The renal biopsy diagnoses were categorized into the following groups: primary glomerulopathies, secondary glomerulopathies, tubulointerstitial diseases, renal vascular diseases, hereditary diseases and unclassified.

Results: Glomerulopathies were the commonest diagnosis, representing 93.34% of all biopsies. Primary glomerulopathies accounted for 87.64% and secondary glomerulopathies for 5.7%. When primary glomerulopathies were further analyzed, minimal change disease was the leading histopathological pattern, found in 29.4% of all biopsies, followed by focal segmental glomerulosclerosis, seen in 21.8% of cases. Among secondary glomerulopathies, lupus nephritis was the commonest, followed by amyloidosis and hemolytic uremic syndrome. Tubu-lointerstitial and vascular diseases were rare, representing 2.8% and 0.8% of all biopsy diagnoses, respectively.


Postdeposition GSK2126458 order anneal results in the recrystallization of BTO films. The electrical measurements exhibit that the BTO films have high capacitance densities and low leakage currents.”
“Cardiac arrhythmias occur in approximately 5.3% of the population and contribute substantially to morbidity and mortality. Pharmacological therapy still remains the major approach in management of patients with nearly every

form of cardiac arrhythmia. Effective and safe management of cardiac arrhythmias with antiarrhythmic drugs requires understanding of basic mechanisms for various cardiac arrhythmias, clinical diagnosis of an arrhythmia and identification of underlying cardiac diseases, pharmacokinetics, and antiarrhythmic properties of each individual antiarrhythmic drug. Most cardiac arrhythmias occur learn more via one of the two mechanisms: abnormal impulse formation and reentry or both. Antiarrhythmic drugs primarily work via influencing cardiac automaticity or triggered activity or by their effects on effective refractoriness of cardiac cells. Proarrhythmic effects of antiarrhythmic drugs are also briefly discussed in this review article. (PACE 2009; 32: 1454-1465)”
“Purpose We sought to identify indicators associated with the quality of life (QoL) of stroke patients and caregivers.


The cross-sectional study was conducted at nine Dutch stroke service facilities involving 251 stroke patients and their caregivers. We used the EuroQol (EQ-5D) and Satisfaction with Stroke Care questionnaires, and included the variables (1) disability at hospital admission, (2) length of hospital stay, (3) demographic data, and (4) caregivers’ relationship with stroke patients. The Actor-Partner (patient-caregiver) Interdependence Model (APIM) was used to examine dependence between patients’ and caregivers’ QoL scores through dyad LDK378 chemical structure membership.

Results Patients’ age was significantly related to their QoL, and caregivers’ age and educational level were significantly

related to their QoL. Patients’ disability on hospital admission and length of stay were associated with patients’ QoL, and their disability on admission was related to caregivers’ QoL. No relationship was found between length of stay and caregivers’ QoL. Satisfaction with care was associated with both patients’ and caregivers’ QoL.

Conclusions The APIM distinguished the different roles of patients and caregivers while acknowledging the interdependence of their QoL scores. Satisfaction with care was identified as important indicator of stroke patients’ and caregivers’ QoL.”
“Capillary torque is induced when a liquid bridge forms between two angle-positioned filaments. This paper aims to study the dependency of such capillary torque upon the filament orientation angle, filament spacing, contact angle, and liquid volume through detailed numerical simulation using a surface finite element scheme.

SETTING: Eye Clinic, Ipoh General Hospital, Ipoh, Perak, Malaysia

SETTING: Eye Clinic, Ipoh General Hospital, Ipoh, Perak, Malaysia.

METHODS: Patients with nonglaucomatous eyes with open angles or with occludable angles were recruited. Ocular biometric measurements (ACD, axial length [AL], lens thickness and position) and IOP (tonometry) were performed preoperatively and 1 day and 1, 4, 9, and 12 weeks postoperatively.


The open-angle group and occludable-angle group each comprised 35 patients. The occludable-angle group had a shallower ACD, shorter AL, thicker and relatively anterior lens position, and higher IOP preoperatively; postoperatively, there was a significant increase in ACD and a significant reduction in IOP (P<.01). Anterior chamber deepening was inversely GSK1838705A solubility dmso related to preoperative ACD in the occludable-angle group (P<.01). The mean preoperative IOP was higher in the occludable-angle group (15.77 mm Hg +/- 2.20 [SD]) than in the open-angle group (14.52 +/- 2.65 mm Hg) (P<.05). The IOP dropped progressively and significantly over 12 weeks postoperatively;

the mean decrease was 2.31 +/- 0.99 mm Hg in the occludable-angle group and 0.77 +/- 1.17 mm Hg in the open-angle group. The IOP decrease in the occludable-angle group was inversely related to the preoperative IOP (P<.01).

CONCLUSION: Phacoemulsification led to anterior chamber deepening and lower IOP in eyes with occludable angles, which suggests it is an option for preventing acute angle closure attacks in eyes with occludable angles and cataract.”
“Trilayer thin films Py/Fe-57/Gd and Gd/Fe-57/Py (Py: Fe20Ni80 permalloy) have been prepared by electron-beam evaporation and investigated using see more conversion-electron Mossbauer spectroscopy

(CEMS), scanning tunneling microscopy (STM), polar magneto-optical Kerr effect (PMOKE), and ferromagnetic resonance (FMR). It was shown that the films deposited in the same vacuum and temperature runs but with the reverse order of the layers gave a different quality of interfaces: sharp (Py/Fe-57/Gd) and rough (Gd/Fe-57/Py). Different distribution of atoms in sharp and rough interfaces results in different magnetic properties: the Mossbauer spectra, FMR, and PMOKE data show the appearance of Selleck BYL719 perpendicular magnetic anisotropy (PMA) and enhancement of magnetization in the samples with the rough Gd/Py interface. (C) 2011 American Institute of Physics. [doi:10.1063/1.3562871]“
“BACKGROUND: Exercise performance, an important aspect of quality of life, remains limited after heart transplantation (HTx). This study examines the effect of cardiac allograft remodeling on functional capacity after HTx.

METHODS: The total cohort of 117 HTx recipients, based on echocardiographic determination of left ventricle mass and relative wall thickness at 1 year after HTx, was divided into 3 groups: (1) NG, normal geometry; (2) CR, concentric remodeling; and (3) CH, concentric hypertrophy. Cardiopulmonary exercise testing was performed 5.

The transcription of HbHsp70 was induced by ethephon, heat treatm

The transcription of HbHsp70 was induced by ethephon, heat treatment and low temperature stress, whereas jasmonic acid had little effects.

Recombinant HbHsp70 was expressed in Escherichia coli and purified by Ni-NTA affinity chromatography. Measuring the light GS-9973 order scattering of luciferase (Luc) revealed that HbHsp70 prevents the aggregation of luc during high-temperature stress. In vitro experiments showed that HbHsp70 had protective functions not only against heat stress but also against chilling stress. All these data suggest that HbHsp70 may play roles in responses to heat shock and low temperature in H. brasiliensis. (C) 2009 Elsevier Masson SAS. All rights reserved.”
“Objective To describe the change in pain and distress over time to demonstrate the effectiveness of the QUICATOUCH program in an outpatient oncology population.

Methods Descriptive study of the first 29 months of the QUICATOUCH program (13736 assessments for 5775 patients). A longitudinal cohort design was used to examine the patients with three or more assessments (8129 assessments for 1778 patients). Effectiveness of check details this complex intervention (repeated assessment, clinician report and referral to speciality psycho-oncology service) was examined using: reduction in proportion over threshold for pain and distress, predictors of mean pain and distress scores and comparison of the number of new patients

treated by the psycho-oncology service during the study and in the preceding 29?months.

Results Pain and distress declined during the study. The risk of being over threshold at endpoint was reduced for pain PFTα solubility dmso (odds ratio (OR) 0.70, confidence interval (CI) 95% 0.600.81) and for distress (OR 0.58 CI 95% 0.490.68) with baseline as referent level. Three variables predicted the mean pain: clinic type, current

radiotherapy treatment and distress score; and five predicted mean distress: time, gender, clinic type, age and pain score. There was an increase of 40% (533v747) in new patients treated by the psycho-oncology service.

Conclusions The QUICATOUCH assessment for pain and distress was implemented into usual clinical practice with reasonable coverage of patients for modest cost. It was effective in monitoring the patients over time, contributed to a reduction in pain and distress, whilst appropriately increasing the number of new patients reaching psychological treatment as part of the clinical service. Copyright (c) 2011 John Wiley & Sons, Ltd.”
“Background: HIV infection increases the risk of placental malaria, which is associated with poor maternal and infant outcomes. Recommendations in Uganda are for HIV-infected pregnant women to receive daily trimethoprim-sulphamethoxazole (TS) and HIV-uninfected women to receive intermittent sulphadoxine-pyrimethamine (SP). TS decreases the risk of malaria in HIV-infected adults and children but has not been evaluated among pregnant women.


Conclusions: Our evidence suggests that spinal c


Conclusions: Our evidence suggests that spinal cord rotation is a strong and significant predictor of C5 palsy postoperatively. Patients can be classified into three types, with Type 1 representing mild rotation (0 degrees to 5 degrees), Type 2 representing moderate rotation (6 degrees to 10 degrees), and Type 3 representing severe rotation (>= 11 degrees). The rate of C5 palsy was zero of 159 in the Type-1 group, eight of thirteen in the Type-2 group, and JNK-IN-8 price four of four in the Type-3 group. This information may be valuable for surgeons and patients considering anterior surgery in the C4 to C6 levels.”
“An N-Halamine biocidal polymer was prepared

by co-polymerizing toluene-2,6-diisocyanate with a new heterocyclic uramil-based azo-monomer, followed by halogenation. The mode of action of N-halamine polymers selleck screening library on bacteria was investigated and halogenation conditions (temperature, halogenation time, halogen concentration) were optimized for bactericidal action against E. coli and S. aureus. It was found that the mode of action of this type

of polymer is a combination of different factors; contact, release, and through interaction of the polymer with the bacterial medium. The most effective halogenation conditions were stirring 1 g polymer in 10 mL sodium hypochlorite (10 %) for 1 h at ambient temperature (22 degrees C). (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 113: 2404-2412, 2009″
“The crystal structure and equation of state (EOS) of aluminum carbide (Al(4)C(3)) have been determined directly up to 50.1 GPa at room temperature by the synchrotron x-ray diffraction techniques. The results indicate that Al(4)C(3) remained in rhombohedral structure under all tested pressure-temperature conditions and exhibited anisotropic compressibility, with the c-axis more compressible than the a-axis. Fitting the experimental data to third order Birch-Murnaghan EOS yields a bulk modulus of K(OT)=233 +/- 6 GPa with its pressure derivative K(OT)’=3.4 +/- 0.4, while the second-order EOS yields K(OT)=223 +/- 2 GPa.

(C) 2009 American Institute of Physics. [doi:10.1063/1.3246808]“
“Background: Unconstrained shoulder arthroplasty is one of several methods for treatment of proximal humeral fracture nonunions. The goal of this study was to define the results Temsirolimus cell line and complications of this procedure.

Methods: From 1976 to 2007, sixty-seven patients underwent unconstrained shoulder arthroplasty for proximal humeral nonunion and were followed for more than two years. There were forty-nine women and eighteen men with a mean age of sixty-four years and a mean duration of follow-up of nine years (range, two to thirty years). The fracture type according to the Neer classification was two-part in thirty-six patients, three-part in sixteen, and four-part in fifteen. Hemiarthroplasty was performed in fifty-four patients and total shoulder arthroplasty was done in the remaining thirteen.


CONCLUSION: These results suggest that the benefit


CONCLUSION: These results suggest that the benefits of OPCAB

in terms of hospital resource use are influenced by sex. The potential beneficial effects are not demonstrated in the female population.”
“Background: Failure to cite prior evidence in the medical literature may result in publication redundancy and inefficient use of research funding. We evaluated trials in which internal fixation was compared with arthroplasty for the treatment of hip fractures in order to determine the extent to which these randomized trials cited all relevant previous trials.

Methods: We searched MEDLINE and Embase for all relevant articles on four topics: internal fixation compared with arthroplasty, total hip arthroplasty compared with

hemiarthroplasty, sliding hip screws compared with other fixation devices, and surgical delay of hip fracture treatment. We determined the proportion of previous studies that selleck chemicals were cited in comparison with the total number of previous studies that were citable (i.e., the citation rate) as well as the proportion learn more of times that a study was cited in comparison with the total number of times that it could have been cited (i.e., the hit rate). A cumulative meta-analysis was performed for the “”internal fixation compared with arthroplasty”" topic to determine whether compelling evidence favoring one intervention existed at an earlier time.

Results: In total, sixty studies were assessed and yielded an overall citation rate of 48%. All “”highly cited”" studies reported a positive result (favoring arthroplasty), and 60% were published in The Journal of Bone and Joint Surgery (American or British volume). The results of a study and the journal of publication significantly affected the hit rate (p <


Conclusions: Our review of studies of hip fracture treatment suggests poor citation of the previous literature. Studies in higher-impact journals with positive results are more likely to be cited in subsequent studies. Therefore, redundancy in publication and unnecessary surgical trials often occur.”
“In Colombia, the mosquito Ochlerotatus taeniorhynchus has been identified as an efficient vector of the epidemic-epizootic Venezuelan equine encephalitis virus. We evaluated the genetic variability and heterogeneity www.selleckchem.com/products/CAL-101.html of this mosquito in Colombian populations using eight microsatellite DNA loci. Two hundred and ten mosquito specimens collected from seven populations of the Colombian Atlantic coast (San Bernardo del Viento, Cove as, Cartagena, Barranquilla, Cienaga, Dibulla, and Riohacha) were analyzed. We found five polymorphic microsatellite loci, with 19 alleles giving 62.5% polymorphism; the mean number of alleles per locus was 3.8. The mean expected heterogeneity ranged from 0.568 to 0.660. Most of the polymorphic microsatellite loci were in Hardy-Weinberg disequilibrium, due to both deficit and excess of heterozygotes. The Fst statistic gave a total value of 0.

(c) 2011 Elsevier Ltd All rights reserved “
“Danazol, a der

(c) 2011 Elsevier Ltd. All rights reserved.”
“Danazol, a derivative of testosterone, is useful for treatment of endometriosis as well as pretreatment for in vitro fertilization and embryo transfer, although its mechanisms of action are unclear. The aim of this study was to investigate the effect

of danazol on alloimmune responses in murine heart transplantation. CBA male mice (H2k) underwent transplantation of C57BL/6 male (H2b) hearts and received a single dose of danazol (0.4, 1.2 or 4 mg/kg/day) by intraperitoneal injection on the day of transplantation and for 6 days thereafter. An adoptive transfer study was performed to determine whether regulatory cells were generated. The median survival time (MST) of allografts in danazol-treated (1.2 and 4 mg/kg/day) mice https://www.selleckchem.com/products/nutlin-3a.html was 28 and 63 days, respectively, compared with 7 days in untreated mice. Moreover, secondary Ion Channel Ligand Library CBA recipients given whole

splenocytes or CD4+ cells from primary danazol-treated (4 mg/kg/day) CBA recipients 30 days after transplantation had prolonged allograft survival (MSTs, 29 and 60 days, respectively). Cell proliferation, interleukin (IL)-2 and interferon-? were suppressed in danazol-treated mice, whereas IL-4 and IL-10 were up-regulated. Moreover, danazol directly suppressed allo-proliferation in a mixed leukocyte culture. Flow cytometry showed an increased CD4+ CD25+ Foxp3+ cell population in splenocytes from danazol-treated mice. Danazol prolongs cardiac allograft survival and generates regulatory CD4+ cells.”
“DNA damage is frequently encountered in spermatozoa of subfertile males and is correlated with a range of adverse clinical outcomes including impaired fertilization, disrupted preimplantation embryonic development, increased rates of miscarriage and an enhanced risk of disease in the progeny. Veliparib manufacturer The etiology of DNA fragmentation in human spermatozoa is closely correlated with the appearance of oxidative base adducts and evidence of impaired spermiogenesis. We hypothesize

that oxidative stress impedes spermiogenesis, resulting in the generation of spermatozoa with poorly remodelled chromatin. These defective cells have a tendency to default to an apoptotic pathway associated with motility loss, caspase activation, phosphatidylserine exteriorization and the activation of free radical generation by the mitochondria. The latter induces lipid peroxidation and oxidative DNA damage, which then leads to DNA fragmentation and cell death. The physical architecture of spermatozoa prevents any nucleases activated as a result of this apoptotic process from gaining access to the nuclear DNA and inducing its fragmentation. It is for this reason that a majority of the DNA damage encountered in human spermatozoa seems to be oxidative. Given the important role that oxidative stress seems to have in the etiology of DNA damage, there should be an important role for antioxidants in the treatment of this condition.

4% of the patients were found to have parental consanguinity We

4% of the patients were found to have parental consanguinity. We conclude that the genetics of familial Mediterranean fever is more complex than has previously been reported; heterozygous patients presenting a severe phenotype should be further analyzed for less common secondary MEFV mutations, using gene sequencing.”
“The rates of Foetal Alcohol Syndrome (FAS) and Partial Foetal Alcohol Spectrum (PFAS) in South Africa are the highest reported worldwide. There is a paucity of research examining the health care costs of caring for children with FAS or PFAS in this


A cross-sectional analytical study was conducted using an interviewer-administered questionnaire amongst caregivers of children (0-12 years) with FAS/PFAS in the Western Cape to estimate the utilization of health care services; the annual direct and indirect health care costs per child as well as the total cost to Selleck MLN2238 society PCI-34051 cost for providing health care services to

children with FAS/PFAS. it was found that the median number of annual visits to public health care facilities per child was 8 (IQR 4 to 14). The total average annual cost per child was $1039.38 (95% Cl: $808.68; $1270.07) and the total annual societal cost for the Western Cape was $70,960,053.68 (95% Cl: $5,528,895.48; $86,709,971.13). Caregivers in receipt of a social support grant reported spending significantly less on health care for a child with FAS/PFAS (Fisher’s exact p = 0.004). These study results confirm the significant burden of FAS/PFAS on the Western Cape economy and the health care system which has significant implications for FAS prevention. (C) 2010 Elsevier Ireland Ltd. All rights reserved.”
“We cancer metabolism inhibitor present two patients with neuromyelitis optica (NMO; Devic’s syndrome), one associated with systemic lupus erythematosus and the other with Hashimoto thyroiditis. Devic’s syndrome, whose initial symptoms and signs mimic those of multiple sclerosis,

can be associated with other autoimmune diseases. We emphasize the importance of ruling out other entities throughout the follow-up. NMO is seldom described in patients with lupus, which may be due to the rare occurrence of this association sometimes leading to its misdiagnosis.”
“Red rod is an economically important disease of sugarcane caused by the fungus Colletotrichum falcatum. We used a simple sequence repeat (SSR)-based marker system to identify and analyze genetic relationships of red rot resistant and susceptible sugarcane cultivars grown in Pakistan. Twenty-one highly polymorphic SSR markers were used for DNA fingerprinting and genetic diversity analysis of 20 sugarcane cultivars. These SSR markers were found to be highly robust; we identified 144 alleles, with 3-11 alleles per marker and a mean of 6.8. Three SSR markers were able to identify all 20 cultivars. DNAMAN (R)-generated homology tree was used to analyze genetic diversity among these cultivars; all cultivars shared 58% or more similarity.