841 – 24.494) Gendera Male
35 median 4.037 0.817 3.200 0.247 0.986 0.611 9.794 0.746 12.670 0.379 (range) (0.427 – 61.171) (0.035 – 17.376) (0.020 Rapamycin – 6.229) (0.000 – 64.312) (0.100 – 45.381) Female 5 median 4.331 1.454 1.191 9.102 19.520 (range) (3.223 – 6.581) (0.677 – 7.218) (0.562 – 2.361) (5.989 – 12.900) (5.367 – 23.448) T classificationb 1 2 coefficient rs = -0.264 0.114 rs = 0.089 0.583 rs = -0.017 0.919 rs = 0.223 0.170 rs = -0.327 0.041* 2 10 3 22 4 6 LN metastasisa N (-) 15 median 2.399 0.037* 2.926 0.964 0.983 0.800 6.947 0.226 18.801 0.020* (range) (0.427 – 6.092) (0.059 – 11.250) (0.193 – 5.137) (0.000 – 42.360) (0.841 – 45.381) N (+) 25 median 4.443 3.602 1.094 12.037 10.688 (range) (1.379 – 61.171) (0.035 – 17.376) (0.020 – 6.229) (0.936 – 64.312) (0.100 – 23.697) Histological gradeb I 21 coefficient rs = 0.155 0.338 rs = 0.462 0.004* rs = 0.374
0.021* rs = 0.381 0.019* rs = -0.026 0.873 II 12 III 7 Vascular invasiona Negative 32 median 3.478 0.133 3.393 0.360 1.006 0.608 9.369 0.913 14.999 0.085 (range) (0.640 – 61.171) (0.035 – 17.376) (0.020 – 5.538) (0.000 – 64.312) (0.100 – 45.381) Positive 8 median 10.759 2.250 1.264 9.794 7.799 (range) (0.427 – 43.355) (0.059 Wnt inhibitor – 6.356) Proteasome inhibitor (0.193 – 6.229) (1.246 – 29.053) (0.841 – 23.697) Lymphatic invasiona Negative 22 median 4.037 0.800 3.939 0.195 0.936 0.554 9.027 0.554 15.966 0.192 (range) (0.640 – 61.171) (0.035 – 11.250) (0 020 – 5.137) (0.000 – 64.312) (1.373 – 38.234) Positive 18 median 4.733 2.155 1.104 10.915 10.694 (range) (0.427 – 60.921)
(0.059 – 17.376) (0.086 – 6.229) (0.936 – 31.933) (0.100 – 45.381) Perineural invasiona Negative 30 median 4.128 0.841 2.212 0.016* 1.006 0.286 7.720 0.008* 14.891 0.617 (range) (0.427 – 61.171) (0.035 – 11.250) (0.020 – 5.137) (0.000 0 64.312) (0.100 – 38.234) Positive 10 median 5.247 6.345 1.114 13.886 11.907 (range) (0.640 – 60.921) (2.250 – 17.376) (0.458 – 6.229) (9.027 – 31.933) (2.089 – 45.381) aMann-Whithey U test, bSpearman rank correlation coefficient. LN = lymph node, rs = correlation coefficient. Univariate and multivariate analyses of risk factors affecting lymph node metastasis To determine the risk factors predictive of lymph node metastasis, we further examined the correlation of lymph node metastasis with other clinicopathological factors. As shown in Table 3, advanced T-classification was significantly correlated with lymph node metastasis (p = 0.036).