A total of 887 subjects aged 12-15 years whose parents/guardians had given a written http://www.selleckchem.com/products/mek162.html informed consent were examined among which 55.9% were males and 44.1% were females. The general information and the clinical examination findings were recorded. The examination for malocclusion was made according to DAI as described in WHO Oral Health Survey Basic Methods, 1997.[11] To reduce the examiner’s bias (diagnostic criteria maintenance), duplicate examination was conducted on 5% (n = 45) of the population during the course of study. There were three differences in the DAI where the error was 1 mm in all of them, resulting in error rate of 0.7462%, which was disregarded (error smaller than 1.00%).

Statistical analysis The recorded data was compiled and entered in a spreadsheet computer program (Microsoft Excel 2007) and then exported to data editor page of Statistical Package for the Social Sciences (SPSS) version 11.5 (SPSS Inc., Chicago, Illinois, USA). The results of intra-examiner reliability were tested using Wilcoxon signed rank test. The validation of the index was performed by calculating sensitivity, specificity, positive predictive value and negative predictive value. Descriptive statistics included computation of percentages, means and standard deviations. The Chi-square test (��2) was used for comparisons of malocclusion prevalence between different age and gender groups. Analysis of variance along with Scheffe’s test was used for comparison of mean DAI scores between the various age groups and changes in DAI scores. t-test was used for comparing the mean DAI scores between gender groups.

For all tests, confidence interval and P value were set at 95% and �� 0.05 respectively. RESULTS Reliability and validity of index There was no statistically significant difference between the measurements for reliability (P = 0.41). The index had great sensitivity and low specificity, indicating a good ability to identify orthodontic treatment need [Table 1]. Table 1 Frequency of orthodontic treatment need comparing diagnosis performed by panel opinion (gold standard) and DAI Distribution of study subjects A total of 887 children (males: 496 [55.9%] and females 391 [44.1%]) participated in the survey [Table 2]. Table 2 Distribution of study subjects by age and gender Distribution of DAI components by age and gender The proportion of children with crowding was significantly highest among 12 years age group (P = 0.

00). A significant association (P = 0.00) of incisal segment crowding with gender was revealed with males portraying a greater prevalence of one segment (31.7%) and two segments crowding (18.5%) than females (One segment crowding: [18.4%], Two segments crowding: [9.2%]). Statistically significant Dacomitinib gender difference evidenced a greater proportion of males ostentatious by 1 mm (12.3%), 2 mm (6.9%) and 3 mm (4.2%) diastema than females who embodied (3.1%), (0.