Chen C, Ridzon DA, Broomer AJ, Zhou see more Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR, et al.: AZD0156 clinical trial Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005, 33: e179.PubMedCrossRef 15. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif) 2001, 25: 402–408. 16. Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC: Isolation and functional properties

of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 1996, 183: 1797–1806.PubMedCrossRef 17. Haraguchi N, Utsunomiya T, Inoue H, Tanaka F, Mimori K, Barnard GF, Mori M: Characterization of a side population of cancer cells CHIR-99021 clinical trial from human gastrointestinal system. Stem Cells 2006, 24: 506–513.PubMedCrossRef 18. Shimano K, Satake M, Okaya A, Kitanaka J, Kitanaka N, Takemura M, Sakagami M, Terada N, Tsujimura T: Hepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1. Am J Pathol 2003, 163: 3–9.PubMedCrossRef 19. Wulf GG, Luo KL, Jackson KA, Brenner MK, Goodell MA: Cells of the hepatic side population contribute to liver

regeneration and can be replenished with bone marrow stem cells. Haematologica 2003, 88: 368–378.PubMed 20. Kloosterman WP, Plasterk RH: The diverse functions of microRNAs in animal development and disease. Dev Cell 2006, 11: 441–450.PubMedCrossRef 21. Zhao Y, Samal E, Srivastava D: Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 2005, 436:

214–220.PubMedCrossRef 22. Lakshmipathy U, Hart RP: Concise review: MicroRNA expression in multipotent mesenchymal stromal cells. Molecular motor Stem Cells 2008, 26: 356–363.PubMedCrossRef 23. He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM: A microRNA polycistron as a potential human oncogene. Nature 2005, 435: 828–833.PubMedCrossRef 24. Stadler BM, Ruohola-Baker H: Small RNAs: keeping stem cells in line. Cell 2008, 132: 563–566.PubMedCrossRef 25. Katoh H, Shibata T, Kokubu A, Ojima H, Loukopoulos P, Kanai Y, Kosuge T, Fukayama M, Kondo T, Sakamoto M, et al.: Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome. J Hepatol 2005, 43: 863–874.PubMedCrossRef 26. Sy SM, Wong N, Lai PB, To KF, Johnson PJ: Regional over-representations on chromosomes 1q, 3q and 7q in the progression of hepatitis B virus-related hepatocellular carcinoma. Mod Pathol 2005, 18: 686–692.PubMedCrossRef 27. Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, et al.: A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005, 353: 1793–1801.PubMedCrossRef 28.