Diagnostic imaging plays a central role in ARM evaluation. Because of the lack of ionizing radiation, excellent intrinsic contrast resolution, multiplanar imaging capabilities, technical advances in hardware, and innovative imaging protocols, magnetic resonance (MR) imaging is increasingly important in assessment of ARM patients in utero, postnatally before definitive surgical DNA-PK inhibitor correction, and in the postoperative period. This article discusses the role of MR imaging in evaluating ARM patients. Matthew R. Hammer, Jonathan R. Dillman, Ethan A. Smith, and Mahmoud

M. Al-Hawary Noninvasive, nonionizing, multiparametric magnetic resonance (MR) imaging of the pelvis using a field strength of 3-T now provides a comprehensive assessment of perineal involvement in pediatric Crohn disease. MR imaging accurately evaluates inflammatory disease activity, and allows determination of the number and course of fistula tracts as well as their relationships Everolimus to vital perianal structures, including the external anal sphincter, helping to guide surgical management and improve outcomes. This article provides an up-to-date review of perineal MR imaging findings of Crohn disease in the pediatric population, including fistulous disease, abscesses, and skin manifestations.

Imaging technique is also discussed. Ethan A. Smith Advances in the treatment of pediatric abdominopelvic malignancies have increased survival drastically. Imaging is critical in initial tumor characterization/staging, assessment of treatment response, and surveillance following therapy. Magnetic resonance imaging (MRI) is playing an increasing role in the care of these patients due to its lack of ionizing radiation, superior contrast resolution and the ability to characterize tumors based on tissue characteristics (e.g., Ergoloid T1 and T2 relaxation times). Modern MR techniques also allow for assessment of tumors based on functional characteristics. This

article is focused on emerging MRI technologies and potential applications in the imaging of pediatric abdominopelvic malignancies. Ranjith Vellody, Peter S. Liu, and David M. Sada Although traditional catheter-based angiography has been the gold standard for pediatric abdominal and pelvic vascular imaging for the past several decades, advances in magnetic resonance angiography (MRA) have made it a viable alternative. MRA offers several advantages in that it is noninvasive, can be performed without ionizing radiation, and does not necessarily rely on contrast administration. The ability of modern MRA techniques to define variant vascular anatomy and detect vascular disease may obviate traditional angiography in some patients. Index 861 “
“Current Opinion in Chemical Biology 2013, 17:506–514 This review comes from a themed issue on Energy Edited by Michael D Burkart and Stephen P Mayfield For a complete overview see the Issue and the Editorial Available online 26th March 2013 1367-5931/$ – see front matter, © 2013 Elsevier Ltd. All rights reserved. http://dx.