finding may suggest that alterations in the expression of these two genes could suggest a predisposition of these patients to endometriosis, as also proved in a previous study. With respect to gene expression of the members of the BCL2 family, this study was struggling to detect a statistically significant difference between women with and without endometriosis and this may be due to the limited number of products readily available for the study. Nevertheless, as illustrated in Figure 3, the BAX and BAK CTEP GluR Chemical appearance were substantially lower and BCL2 higher in the endometriotic group in contrast to girls without endometriosis and these differences were most obvious for 2 pro apoptotic factors: BAX and BAK. In improvement, qPCR analysis showed an of the antiapoptotic factor survivin in the types of endometriosis patients and a decreased value of BCL2/ BAX relation, which is important to determine susceptibility to apoptosis in the controls, demonstrating that natural apoptosis is paid off in women with endometriosis. The mRNA concentrations of the BCL XL, another antiapoptotic factor, were comparable in both women groups. But, the BCL XL is just one of two isoforms of the BCL X gene and the BCL XL/BCL Metastasis XS relation is necessary to set an apoptotic ceiling in unaffected cortical tissue of ovaries with endometriotic lesions. Further studies are essential in this region. Based on the histological analysis, the number of resting follicles observed in endometriotic ovaries was paid down as compared with normal ovaries. Particularly, how many primordial and primary follicles was significantly lower in ovaries than in normal ones. Several researchers have also noticed that women with advanced stage endometriosis, who’ve undergone previous CX-4945 Protein kinase PKC inhibitor surgery, respond less to gonadotrophins as compared with women with tubal factor infertility. Consequently, the follicular ovarian reserve could be impaired in patients treated for large, deep ovarian endometriomas. It’s postulated here that the decreased follicular reserve in patients with ovarian endometriosis couldn’t be related only to the amount of ovarian tissue removed during surgery and that a functional disturbance of the ovarian cortex may be present before surgery. This theory is supported by the outcome reported by Kaplan et al. and Maneschi et al.. Consequently, the possible existence of implicit low functional ovarian tissue must be studied into consideration when proposing the medical management of ovarian endometriotic cysts.