? In our study, atelectasis was the most likely cause of early posttraumatic lung dysfunction in more than half of patients, and only 20% of patients had Mlung values in the range previously reported for ALI.? Trauma patients with atelectasis may require shorter periods http://www.selleckchem.com/products/AZD2281(Olaparib).html of mechanical ventilation and treatment in the ICU.? In the future, information from qCT could aid in managing patients with early posttraumatic lung dysfunction.AbbreviationsAECC: American-European Consensus Conference on Acute Respiratory Distress Syndrome; AIS-T: Abbreviated Injury Scale of the Thorax; ALI: acute lung injury; ANOVA: analysis of variance; ARDS: acute respiratory distress syndrome; 95% CI: 95% confidence interval; CT: computed tomography; FiO2: fraction of inspired oxygen; GCS: Glasgow Coma Scale; HU: Hounsfield units; ICU: intensive care unit; IQR: interquartile range; ISS: Injury Severity Score; LIS: Lung Injury Score; Mlung: lung weight; PaO2: arterial partial pressure of oxygen; PEEP: positive end-expiratory pressure; qCT: quantitative analysis of computed tomography; TTSS: Thoracic Trauma Severity Score; Vlung: lung volume.

Competing interestsThe authors declare that they have no competing interests.Authors’ contributionsAWR and APR contributed equally to this work. AWR, APR, DS, MS, CJ and MBPA planned the study. AWR, APR, DS, MS, HB, and UG were responsible for the data acquisition. AWR, APR, TH, AR, MS, HB, SB and UG performed the quantitative CT analysis. AWR, PMS, HW, MGA and MBPA undertook the statistical analysis. All authors contributed to the preparation of the manuscript.

The principal investigators, AWR and APR, had full access to the data analyzed in the study and take full responsibility for the integrity of all of the data and the accuracy of the data analysis.AcknowledgementsInstitutional funding was provided by Leipzig University Hospital.
The pandemic 2009 influenza A (H1N1) virus infection was first described in Mexico in April 2009, and several reports have been published regarding the presentation of this disease with severe acute respiratory symptoms in hospitalized patients [1]. However, the information regarding the incidence and impact of renal failure among these patients remains scarce. The World Health Organization (WHO) warned physicians that patients H1N1 virus infection might develop renal impairment ranging from just mild disease to the need for renal replacement therapy (RRT) [1-5].In critical care settings, many studies are limited because they lack a AV-951 uniform definition of acute kidney injury (AKI). The definition of AKI varies widely and is predominately based on large increments of serum creatinine kinase (CK), thus ignoring milder stages of AKI.