019) was an independent predictor of campesterol values (R of the model = 0.473, P < .001). The E4 allele (beta = .293, P = .005) and high-density lipoprotein
cholesterol (p = .311, P = .003) were independent predictors of sitosterol values (R 0.416, P of the model < .001).
CONCLUSIONS: In patients with hyperlipidemias, G allele of NPC1L1 and APO E4 could account for some of the inter-individual variability in cholesterol absorption. (C) 2013 National Lipid Association. All rights reserved.”
“Purpose of review
Millions of youth sustain concussion each year; although most fully recover following an isolated concussion, a significant minority develop prolonged symptoms and disability following concussion. This article reviews recent data regarding the epidemiology of postconcussion syndrome (PCS) and recommendations see more www.selleckchem.com/products/pexidartinib-plx3397.html for the evaluation and management of postconcussive symptoms in pediatrics.
Recent findings
PCS is a constellation of symptoms related to head injury including somatic symptoms, sleep dysregulation, cognitive deficits and emotional disturbance. Postconcussive symptoms affect 1.5-11% of concussed youth for more than 1 month after injury, depending on the population studied. Girls have a higher risk of postconcussive headache but it is not clear
if cognitive recovery differs between the sexes. Advanced neuroimaging techniques demonstrate a correlation between postconcussive symptoms and functional buy EPZ-6438 neurological changes. However, pre-existing and psychosocial factors also affect risk for prolonged PCS. Current treatment strategies are based mainly on expert opinion and studies of related syndromes.
Summary
Although
a minority of concussed youth develop prolonged PCS, those who are affected can develop significant disability. Prolonged postconcussive symptoms are likely due to interactions between the biological injury, pre-existing risk factors and psychosocial issues. Further research is essential to improve outcomes for this vulnerable population.”
“Introduction The purpose of this study was to determine whether fusion causes adjacent segment degeneration or whether degeneration is due to disease progression.
Materials and methods Eighty-seven patients that had undergone single level anterior cervical decompression and fusions with at least 5 years of follow-up were enrolled in this retrospective study. Segments adjacent to fusion levels (above or below) were allocated to group A, and all others were allocated to group B. Radiographic evaluations of adjacent level changes included assessments of; disc degenerative changes, anterior ossification formation, and segmental instability. The developments of new clinical symptoms were also evaluated.
Results In group A, adjacent segment degenerative change developed in 28 segments (16%) and two cases (2%) developed new clinical symptoms. In group B, adjacent segment degenerative change developed in 10 segments (3%), and two cases (0.