Median APRI at entry were similar (0.53 vs 0.49 vs 0.50) in those who reported no THC use,

log HCV RNA [HR 1.3 (1.10-1.54) p=0.002] and log HIV RNA [HR 1.14 (1.02-1.29) p=0.03] at entry were associated with progression to severe fibrosis; higher Kinase Inhibitor Library nmr CD4+ count [per 50 cells HR 0.96 (0.93-0.98) p<0.0004] was associated with lower fibrosis; whereas cumulative alcohol use [risk per 1 drink increase per week [HR 1.03 (1.02-1.04) p<0.001] was associated with greater risk of progression at follow-up. In multivariate analysis, entry APRI, HCV RNA, CD4+ count and cumulative alcohol use remained significant. Cumulative THC use was not independently associated with a greater risk of fibrosis progression [HR 1.00 (95% CI 0.996-1.003)] even in those with moderate fibrosis at entry [HR 1.00 (95% CI 0.995-1.005)]. CONCLUSION In this large cohort of HCV/HIV co-infected women, THC use was not associated with liver fibrosis progression. Prospective collection of cumulative alcohol and THC use provided granular data to associate with predictors of liver fibrosis. Interestingly, alcohol https://www.selleckchem.com/products/CP-690550.html use was strongly associated with

THC use and independently associated with liver fibrosis, and may better predict fibrosis progression in HCV/HIV co-infected women. Disclosures: Phyllis Tien – Advisory Committees or Review Panels: BMS; Consulting: Genentech Marion G. Peters – Advisory Committees or Review Panels: Janssen; Consulting: Merck; Employment: Hoffman La Roche -Spouse The following people have nothing to disclose: Erin Kelly, Jennifer L. Dodge, Monika Sarkar, Audrey Tau-protein kinase French, Marshall Glesby, Elizabeth T. Golub, Michael Augenbraun, Michael Plankey Introduction: On-treatment HCV RNA measurements are crucial for the prediction of a sustained virological response (SVR) and

to determine treatment futility during several direct antiviral-based HCV triple therapies. In patients with advanced liver disease an accurate risk/benefit calculation based on reliable HCV RNA results can reduce the number of serious adverse events as well as save costs. However, currently recommended treatment algorithms are based on a single HCV RNA assay that is rarely used in clinical practice. The different available HCV RNA assays vary in their diagnostic performances, which may have important clinical implications. Aim: To investigate the clinical relevance of concordant and discordant HCV RNA results of the two most widely used HCV RNA assays during triple therapy with boceprevir and telaprevir in patients with advanced liver fibrosis/cirrhosis.