Some of these could be modified to possibly reduce the incidence of the condition. (C) 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd.
All rights reserved.”
“Objectives: To advance the understanding of the relationship between maternal perinatal depression and child overweight, we used appropriate methodology to account for missing data; incorporated three exposure time points; and included adequate Selleckchem CP690550 covariate adjustment in a large, sociodemographically diverse sample.
Study Design and Setting: We used data from 6,782 mother-child pairs in a prospective population-based study. Maternal depression was assessed with the Brief Symptom Inventory at midpregnancy and 2 and 6 months postpartum. Child height and weight were measured at 36 months of age and converted to body mass index (BMI) z-scores. We compared the complete-case and multiple imputation (MI) analyses.
Results: Fully adjusted complete-case ML323 nmr models showed a positive association between depression at 2 months postpartum and child BMI z-score (beta = 0.19 [95% confidence interval (CI) = 0.03, 0.36]; n = 1,732), and no association between prenatal depression or 6-month postpartum depression and child BMI. Using MI (n = 6,782), there was no association between perinatal depression and child BMI at any time point.
Conclusions: Our study adds evidence
that postpartum depression is not associated with child growth across the population in high-income countries. Our results highlight the importance of appropriate handling of missing data, adequate covariate control, and the value of studying the conditions
that have produced conflicting evidence regarding perinatal depression and child weight. (C) 2012 Elsevier Inc. All rights reserved.”
“Purpose of review
There is buy THZ1 currently limited ability to identify which infants and young children with recurrent wheezing will ultimately develop persistent asthma. In addition, it is not clear how risk factors influence the development of asthma in later childhood and adulthood. This review will discuss efforts to categorize these children with recurrent wheezing and develop asthma-predictive tools.
Recent findings
Transient and persistent wheezing phenotypes have been identified with atopy, reduced lung function, and viral and bacterial respiratory infection as major risk factors for persistence of asthma. Children with severe asthma tend to have greater magnitude of atopy and lower lung function than those with mild-moderate asthma. These phenotypes and risk factors have been described in previous studies and are supported by the recent literature.
Summary
Heterogeneity of wheezing phenotypes may account for different responses to treatment and varied outcomes. Overlap in phenotypes and instability over time also add additional challenges to defining discrete groups of children with specific outcomes.