Using a novel magnetic resonance imaging

(MRI) technigue, we previously showed that pancreatic steatosis may be related to hepatic steatosis in patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD) (Patel et al. APT 2013). This study was limited by the lack of a control group. In addition, the association between insulin resistance and pancreatic fat remains to be evaluated. Aim: To compare pancreatic fat in patients with NAFLD and healthy controls using a novel MRI technigue PCI-32765 concentration and to determine whether pancreatic fat is associated with hepatic steatosis and insulin resistance. Methods: A nested case-control study was derived from two cross-sectional studies of 43 adults with biopsy-proven NAFLD and 49 healthy controls who underwent clinical evaluation, biochemical testing and MRI. Pancreas and liver fat were guantified using a validated MRI this website measurement, the proton density fat fraction (PDFF).

Results: Compared to controls, patients with NAFLD had a higher BMI (31.5 vs.25.5, P< 0.001) and higher proportion of males (55.8% vs.22.5%, P < Disclosures: Claude B. Sirlin - Advisory Committees or Review Panels: Bayer, ISIS, Bayer, ISIS; selleck chemicals llc Consulting: Genzyme, Gilead, Siemens; Grant/Research Support: GE, Bayer, GE, Bayer, Pfizer; Speaking and Teaching: Bayer, Bayer Rohit Loomba – Consulting: Gilead Inc, Corgenix Inc; Grant/Research Support: Daiichi Sankyo Inc, AGA The following people have nothing to disclose: Niraj

Patel, Michael R. Peterson, Grace Y. Lin, Richele Bettencourt Background: Phase contrast Magnetic Resonance Imaging (PCMRI) is a non-invasive technigue used to measure blood flow in the liver; however long acguisition times can limit its use in the clinic. Purpose: To measure blood flow in the portal vein (PV) and hepatic artery (HA) using a high resolution highly accelerated compressed sensing (PC-SPARSE) technigue and to correlate hepatic flow parameters with the presence of PH (portal hypertension). Methods: This was a retrospective, IRB approved study in 76 patients (M/F 48/28, mean age 54 y) who underwent MRI including PC-MRI. Flow, mean velocity, and vessel area were measured in the PV and HA. Arterial fraction (ART = HA flow/[HA flow + PV flow]*100) was calculated. PH score was calculated based on MRI findings.